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The type‐1 repeats of thyroglobulin regulate thyroglobulin degradation and T3, T4 release in thyrocytes
Author(s) -
Molina Franck,
Pau Bernard,
Granier Claude
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00708-9
Subject(s) - thyroglobulin , proteases , chemistry , degradation (telecommunications) , proteolysis , biochemistry , hormone , proteolytic enzymes , thyroid , endocrinology , enzyme , biology , telecommunications , computer science
Thyroglobulin (Tg) proteolytic steps are central phenomena in Tg processing and thyroid hormone release in thyrocytes. Based on recent literature data, we propose that the type‐1 repetitive units present in the Tg sequence could act as binders and reversible inhibitors of the proteases implicated in Tg processing. The pH‐dependent interactions of proteases with the repeats could permit (i) protection from degradation of low iodinated Tg to be recycled; (ii) restriction of early proteolytic attacks to N‐ and C‐terminal hormone formation sites; (iii) increase of the half‐time of acidic proteases necessary for the final, extensive degradation steps of Tg.