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Nitric oxide donor induces HSP70 accumulation in the heart and in cultured cells
Author(s) -
Malyshev Igor Yu.,
Malugin Alexander V.,
Golubeva Lidia Yu.,
Zenina Tatiyana A.,
Manukhina Eugenia B.,
Mikoyan Vasak D.,
Vanin Anatoly F.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00691-6
Subject(s) - hsp70 , nitric oxide synthase , shock (circulatory) , heat shock protein , chemistry , nitric oxide , microbiology and biotechnology , biochemistry , medicine , biology , gene , organic chemistry
As our group has shown, the NO‐synthase inhibitor L‐NNA decreased 2–3 times heat shock‐induced synthesis of the heat shock protein HSP70 (FEBS Lett. 370 (1995) 159–162). It was suggested that NO is involved in such induction. In the present study, it was found that (1) injection of the NO donor dinitrosyl iron complex (DNIC) into rats results in accumulation of HSP70 in the heart; (2) heat shock is accompanied by increased generation of NO (EPR assay) and HSP70 accumulation in cultured cells; (3) DNIC induces HSP70 accumulation in cultured cells not exposed to heat shock.