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The level of pancreatic PLA 2 receptor is closely associated with the proliferative state of rat uterine stromal cells
Author(s) -
Tessier Christian,
Rossini Gian-Paolo,
Pageaux Jean-François,
Cohen Hélène,
Lagarde Michel,
Laugier Christian,
Fayard Jean-Michel
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00680-1
Subject(s) - stromal cell , intracellular , receptor , cell growth , endocrinology , medicine , cell , chemistry , microbiology and biotechnology , enzyme , biology , biochemistry , cancer research
Rat uterine stromal cells (U III ) express pancreatic type PLA 2 (PLA 2 ‐I) receptor and internalize the enzyme bound to receptors. Here, we investigate the proliferating effect and alterations in binding of PLA 2 ‐I. There is a dramatic decline in PLA 2 ‐I binding in U III cells as they progress from a nonconfluent proliferating state (40,000 sites/cell) to a confluent state (1300 sites/cell). Intracellular concentration of PLA 2 ‐I changed with the alteration in binding, suggesting that regulation in the PLA 2 binding capacity may have important implications in growth control mechanisms.