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Potential roles of heterotrimeric G proteins of the endomembrane system
Author(s) -
Nürnberg Bernd,
Ahnert-Hilger Gudrun
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00584-4
Subject(s) - heterotrimeric g protein , endomembrane system , microbiology and biotechnology , intracellular , g protein , organelle , g protein coupled receptor , effector , biology , membrane protein , receptor , secretion , chemistry , biochemistry , signal transduction , membrane , golgi apparatus , endoplasmic reticulum
Heterotrimeric G proteins are recognized as versatile switches linking cell surface receptors to cellular effectors. BesiDA their location at the plasma membrane G proteins are found on intracellular membranes. Studies with modulators of G protein activity suggest that G proteins associated with organelle membranes are involved in various steps of secretion and vesicular function. In contrast to hormonal responses involving G proteins little is currently known about possible receptors or activators and effectors interacting with intracellular G proteins. This short review focuses on recent DAvelopments elucidating the role of organelle‐associated G proteins.