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Role of ascorbic acid in the metabolism of S ‐nitroso‐glutathione
Author(s) -
Kashiba-Iwatsuki Misato,
Yamaguchi Makiko,
Inoue Masayasu
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00560-1
Subject(s) - ascorbic acid , glutathione , chemistry , metabolism , nitroso , biochemistry , nitroso compounds , nitric oxide , reagent , enzyme , organic chemistry , food science
Although nitric oxide (NO) has been known to generate S ‐nitroso‐thiols (RSNOs), dynamic aspects of their metabolism remain to be elucidated. The present work reports the reactivity of S‐nitroso‐glutathione (GS‐NO) with various compounds with reducing activity. Kinetic analysis revealed that among various reagents tested, ascorbic acid showed a potent activity to decompose GS‐NO to glutathione and oxidized products of NO. During the reaction of GS‐NO and ascorbic acid, monodehydroascorbate was found to appear as an intermediate. These results suggest that ascorbic acid might be an important modulator for RS‐NO metabolism.