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Cytotoxic and chemotactic potencies of several aldehydic components of oxidised low density lipoprotein for human monocyte‐macrophages
Author(s) -
Müller Karin,
Hardwick Simon J.,
Marchant Christine E.,
Law Nadine S.,
Waeg Georg,
Esterbauer Hermann,
Carpenter Keri L.H.,
Mitchinson Malcolm J.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00559-5
Subject(s) - cytotoxic t cell , hexanal , chemotaxis , chemistry , low density lipoprotein , monocyte , lipoprotein , biochemistry , lipid peroxidation , malondialdehyde , in vitro , antioxidant , cholesterol , immunology , biology , organic chemistry , receptor
We have investigated the cytotoxic and chemotactic potencies of malondialdehyde (MDA), hexanal, 4‐hydroxyhexenal (HHE), 4‐hydroxynonenal (HNE) and 4‐hydroxyoctenal (HOE), which are aldehydes found in oxidised low density lipoprotein (LDL), for human monocyte‐macrophages. They were toxic in the following order: hexanal < HHE = HOE < HNE. HNE was toxic at 20 μM and chemotactic at 2.5 μM. The other aldehydes tested had no chemoattractant activity. Our results suggest that HNE arising from LDL oxidation could attract monocytes into the human atherosclerotic lesion. A direct cytotoxic role of aldehydes in foam cell death in the lesion is less likely.