Premium
Molecular mechanisms in the disassembly and reassembly of the mammalian Golgi apparatus during M‐phase
Author(s) -
Misteli Tom
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00518-2
Subject(s) - golgi apparatus , microbiology and biotechnology , telophase , mitosis , copi , cell plate , cytoplasm , biology , organelle , chemistry , vesicle , secretory pathway , metaphase , endoplasmic reticulum , cytokinesis , cell , biochemistry , cell division , membrane , chromosome , gene
The mitotic disassembly and reassembly of the mammalian Golgi apparatus is an iDAal system to study the molecular mechanisms involved in biogenesis and maintenance of membranous organelles. As cells enter M‐phase, Golgi stacks are converted into Golgi clusters of small membrane fragments, which are dispersed throughout the cytoplasmic space during metaphase. Disassembly is DApenDAnt on the action of cdc2‐kinase and at least two distinct pathways contribute to the fragmentation: one involves the budding of COP I‐coated vesicles from Golgi cisternae, the other is a less well characterised COP I‐inDApenDAnt pathway. During telophase, the Golgi fragments reassemble and fuse into a fully functional Golgi stack, using at least two distinct ATPase‐mediated fusion pathways.