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New forms of HMW MAP2 are preferentially expressed in the spinal cord
Author(s) -
Couchie Dominique,
Chabas Sandrine,
Mavilia Carmelo,
Nunez Jacques
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00501-7
Subject(s) - exon , spinal cord , biology , microbiology and biotechnology , gdf7 , genetics , neuroscience , gene , embryonic stem cell
The high molecular weight forms of microtubule‐associated protein 2 (MAP2a and b) play a central role in the specification of dendrites. RT‐PCR amplification of a portion of the N‐terminal and middle MAP2b domains of rat spinal cord cDNAs allowed identification of new variants containing both exon 8 (246 bp) and a new exon, 7A (237 bp), located at the beginning of the middle MAP2b region. The brain and the spinal cord express transcripts containing exon 8, whereas exon 7A alone or exons 7A+8 were detected, whatever the developmental stage, only in the spinal cord.