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Effects of phorbol esters on insulin‐induced activation of phosphatidylinositol 3‐kinase, glucose transport, and glycogen synthase in rat adipocytes
Author(s) -
Standaert M.L.,
Bandyopadhyay G.,
Galloway L.,
Farese R.V.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00492-9
Subject(s) - phosphatidylinositol , protein kinase c , insulin , glycogen synthase , gsk 3 , glycogen , medicine , chemistry , endocrinology , phorbol ester , glucose transporter , phorbol , adipocyte , kinase , biochemistry , biology , adipose tissue
In rat adipocytes, phorbol ester‐induced activation of PKC did not inhibit insulin signalling through IRS‐1‐dependent phosphatidylinositol (PI) 3‐kinase activation. Moreover, phorbol esters alone provoked an increase in membrane PI 3‐kinase activity. These findings may be relevant to the failure of phorbol esters to inhibit insulin effects on glucose transport and glycogen synthesis in rat adipocytes.