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Molecular structure and genetic mapping of the mouse gastrin gene
Author(s) -
Friis-Hansen Lennart,
Rourke Ian J.,
Bundgaard Jens R.,
Rehfeld Jens F.,
Samuelson Linda C.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00430-9
Subject(s) - gastrin , biology , gene , exon , pancreas , microbiology and biotechnology , medicine , endocrinology , genetics , secretion
The mouse gastrin gene has three exons totalling 460 bp and a deduced preprogastrin of 101 amino acids. The sequence of murine gastrin‐34 is 94% identical to rat gastrin‐34 and 76% identical to human gastrin‐34. At Arg 79 , mouse progastrin has a unique cleavage site that might allow species‐specific synthesis of gastrin‐13. Northern analysis and RT‐PCR demonstrated that gastrin gene transcripts are abundant in mouse stomach and duodenum and present at low levels in brain, ovary and pancreas, similar to the pattern described for other mammals. The gastrin gene was mapped to the distal region of mouse chromosome 11.