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Human high affinity, Na + ‐dependent l ‐glutamate/ l ‐aspartate transporter GLAST‐1 (EAAT‐1) : gene structure and localization to chromosome 5p11‐p12
Author(s) -
Stoffel Wilhelm,
Sasse Jürgen,
Düker Maria,
Müller Rolf,
Hofmann Kay,
Fink Thomas,
Lichter Peter
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00424-3
Subject(s) - glutamate aspartate transporter , glutamate receptor , exon , neurotransmitter transporter , gene , transporter , microbiology and biotechnology , biology , intron , amino acid transporter , genetics , excitatory amino acid transporter , receptor
The gene of the human l ‐glutamate transporter hGLAST‐1 (EAAT‐1) has been isolated and characterized. The 1626 bp cDNA open reading frame (542 aa) is distributed over ten exons and at least 85 kb on chromosome 5p11‐p12. The gene is unrelated to any other previously described neurotransmitter transporter gene family, but its exon/intron structure corresponds largely to that of the Na + ‐dependent neutral amino acid transporter ASCT‐1. GLAST‐1, ASCT‐1 and the glutamate transporters GLT‐1 and EAAC‐1 have strongly similar amino acid sequences. The l ‐glutamate transporter gene structures might help to understand the correlation of l ‐glutamate reuptake in neurodegenerative disorders.