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RNGB: a Dictyostelium RING finger protein that is specifically located in maturing spore cells
Author(s) -
Kawata Takefumi,
Steel Jane B.,
Williams Jeffrey G.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00411-5
Subject(s) - zinc finger , ring finger , ring finger domain , homeotic gene , dictyostelium , phd finger , biology , dictyostelium discoideum , microbiology and biotechnology , sequence motif , cytoplasm , lim domain , dna , biochemistry , transcription factor , gene
The RING finger is a form of zinc finger motif found in proteins of widely varying biological function. The Dictyostelium RNGB protein contains a RING finger and also a K‐box, a sequence motif found in several plant homeotic proteins. The rngB mRNA is present at low concentration in growing cells and gradually increases in abundance throughout development. However, the RNGB protein is not detected until culmination and we present evidence that suggests it is translationally regulated. The protein is specifically localised in maturing spore cells and is cytoplasmic, suggesting that the RING finger does not function as a DNA binding domain.