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Circadian rhythm in the Ca 2+ ‐inhibitable adenylyl cyclase activity of the rat striatum
Author(s) -
Chern Yijuang,
Lee Eminy H.Y.,
Lai Hsing-Lin,
Wang Hai-Long,
Lee Yi-Chao,
Ching Yung-Hao
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00370-5
Subject(s) - adenylyl cyclase , circadian rhythm , medicine , endocrinology , striatum , agonist , antagonist , chemistry , adenosine , dopamine , biology , receptor , stimulation
In the present study, we demonstrate that the Ca 2+ ‐inhibitable adenylyl cyclase (AC) activity in the striatum exhibits a daily oscillation with a peak occurring around 10:00 h. A circadian fluctuation of the AC activity evoked by an A2a adenosine‐selective agonist was also observed. Intrastriatal injection of an A2a‐selective adenosine agonist or antagonist during the interval in which the Ca 2+ ‐inhibitable AC activity was at its peak resulted in a more significant alteration of locomotor activity than those observed at a later interval. The marked circadian variation in the Ca 2+ ‐inhibitable AC activity in the striatum appears to cause a circadian fluctuation in the action of at least one neuromodulator.