Premium
Stimulation of human peripheral blood lymphocytes by bioactive peptides derived from bovine milk proteins
Author(s) -
Kayser Holger,
Meisel Hans
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00207-4
Subject(s) - stimulation , in vitro , dna synthesis , chemistry , leucine , peptide , endocrinology , medicine , biochemistry , microbiology and biotechnology , biology , amino acid
The in vitro modulation of the proliferation of human peripheral blood lymphocytes of different synthetic peptides derived from milk proteins was investigated. Therefore, proliferation changes were followed up after incorporation of BrdU into the DNA, and the influence on protein biosynthesis was measured using the [ 3 H]leucine incorporation test. Tyr‐Gly and Tyr‐Gly‐Gly significantly enhanced (maximal 90 and 35%, respectively) the proliferation of PBL. For β‐casomorphin‐7 and β‐casokinin‐10, lymphocyte proliferation was suppressed at lower concentrations, but stimulated at higher concentrations (≥10 −7 mol/l). Protein synthesis was stimulated (maxima at 25%) only with Tyr‐Gly and Tyr‐Gly‐Gly. The findings point to a need for further studies on the possible function of peptides derived from milk proteins as orally bioavailable immunopotentiatory compounds.