Acidic phospholipids inhibit the phospholipase D activity of rat brain neuronal nuclei | Zendy

Kanfer J.N. | Zendy; McCartney D.G. | Zendy; Singh I.N. | Zendy; Freysz L. | Zendy

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Acidic phospholipids inhibit the phospholipase D activity of rat brain neuronal nuclei

Author(s) -

Kanfer J.N.,

McCartney D.G.,

Singh I.N.,

Freysz L.

Publication year - 1996

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/0014-5793(96)00205-0

Subject(s) - phosphatidic acid , phospholipase d , phospholipase , phospholipase a2 , hydrolysis , chemistry , phospholipase a1 , biochemistry , phospholipase c , disinhibition , phospholipase a , enzyme , phospholipid , biology , neuroscience , membrane

An oleate dependent form of phospholipase D is present in rat brain neuronal nuclei and both the hydrolytic and transphosphatidylation activities measured. Several acidic phospholipids were found to inhibit this activity in a dose dependent manner. The IC 50 values varied from 3.5 μM for PIP 2 to 200 μM for phosphatidic acid. The hydrolysis of PIP 2 by phospholipase C would be expected to result in the disinhibition of the oleate dependent phospholipase D activity.

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