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Identification of RII‐binding proteins in the mollusc Mytilus galloprovincialis
Author(s) -
Cao Jesús,
Fernández Montserrat,
Ramos-Martínez J.Ignacio,
Antonio Villamarín J
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00158-5
Subject(s) - mytilus , mussel , protein subunit , biology , binding protein , protein kinase a , in vitro , biochemistry , microbiology and biotechnology , gene , fishery , kinase
Several proteins with M r 70 kDa from various tissues of the sea mussel Mytilus galloprovincialis were specifically recognized in vitro by the regulatory subunit (type RIIα) of cAMP‐dependent protein kinase (cAPK) from porcine heart. However, none of these proteins interacted with the regulatory subunit of cAPK from the mollusc itself. The results suggest that, unlike mammalian RII, regulatory subunit from mussel lacks the specific residues responsible for interaction with R‐binding proteins. Consequently, the identified molluscan RIIα‐binding proteins should play a distinct role from cAPK anchoring.