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Multiple transduction pathways regulate the sodium‐extrusion gene PMR2/ENA1 during salt stress in yeast
Author(s) -
Märquez JoséA,
Serrano Ramón
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00157-3
Subject(s) - yeast , signal transduction , chemistry , biochemistry , calcineurin , sodium , phosphatase , protein kinase a , kinase , microbiology and biotechnology , enzyme , biology , medicine , transplantation , organic chemistry
The yeast PMR2/ENA1 gene encodes an ATPase involved in sodium extrusion and induced by NaCl. At low salt concentration (0.3 M) induction is mediated by the HOG‐MAP kinase pathway, a system activated by non‐specific osmotic stress. At high salt concentrations (0.8 M) induction is mediated by the protein phosphatase calcineurin and is specific for sodium. Protein kinase A and Sis2p/Hal3p modulate PMR2/ENA1 expression as negative and positive factors, respectively but Sis2p/Hal3p does not participate in the transduction of the salt signal. Salt stress decreases the level of cAMP and the resulting decrease in protein kinase A activity may contribute to HOG‐mediated induction.