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Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats
Author(s) -
Bömer Ulf,
Pfanner Nikolaus,
Dietmeier Klaus
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00156-1
Subject(s) - translocase , translocase of the outer membrane , translocase of the inner membrane , biology , inner mitochondrial membrane , mitochondrial carrier , saccharomyces cerevisiae , cytosol , protein targeting , inner membrane , biochemistry , atp–adp translocase , mitochondrion , bacterial outer membrane , microbiology and biotechnology , yeast , membrane protein , mitochondrial membrane transport protein , chromosomal translocation , gene , membrane , enzyme , escherichia coli
The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein‐protein interactions. We have identified Saccharomyces cerevisiae Tom72, a new Tom protein expressed at a low level. Tom72 is homologous to Tom70, including seven tetratrico peptide repeats. Tom72 is targeted to the mitochondrial outer membrane, forms a large domain exposed to the cytosol and loosely associates with the translocase complex of the outer membrane. These results suggest that Tom72 represents a ninth, weakly expressed component of the preprotein translocase of the mitochondrial outer membrane.