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Identification of alternative splicing form of Stat2
Author(s) -
Sugiyama Tetsuya,
Nishio Yukihiro,
Kishimoto Tadamitsu,
Akira Shizuo
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00121-4
Subject(s) - computational biology , identification (biology) , alternative splicing , biology , chemistry , biochemistry , gene , exon , botany
We identified alternatively spliced forms of Stat2 in human and mouse mRNAs. The spliced forms are generated by reading through the intron between exon 20 and 21, which correspond to the region encoding SH2 domain. The spliced forms contain a stop codon in SH2 domain, and therefore give rise to a short form of Stat2 when the mRNAs are translated. The putative translated proteins lack half of the SH2 domain, the tyrosine phosphorylation site required for dimerization (or oligomereization) and DNA binding, and C‐terminal activation domain. The significance of these spliced forms is discussed.