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Interferons induce accumulation of diadenosine triphosphate (Ap 3 A) in human cultured cells
Author(s) -
Vartanian A.,
Narovlyansky A.,
Amchenkova A.,
Turpaev K.,
Kisselev L.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00073-7
Subject(s) - incubation , myeloid leukemia , hl60 , interferon , microbiology and biotechnology , haematopoiesis , chemistry , function (biology) , k562 cells , biochemistry , biology , in vitro , cancer research , immunology , stem cell
After incubation of human monocytes J96 and human myeloid leukemia HL60 cells with interferons (IFN) α or γ, the Ap 3 A concentration considerably increases in parallel with accumulation of tryptophanyl‐tRNA synthetase (TrpRS, EC 6.1.1.2) The Ap 3 A formation in response to IFNs is catalysed by an excessive amount of TrpRS. Although the Ap 3 A function still remain unknown its accumulation may imply the Ap 3 A involment in the IFN‐signalling pathway.