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Comparative studies of gamma‐interferon receptor‐like proteins of variola major and variola minor viruses
Author(s) -
Seregin Sergei V,
Babkina Iri,
Nesterov Andrei E,
Sinyakov Aleksander N,
Shchelkunov Sergei N
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00069-5
Subject(s) - variola virus , virology , smallpox , biology , vaccination , vaccinia , biochemistry , recombinant dna , gene
To study specific properties of the human gamma‐interferon (γ‐IFN) receptor‐like proteins of the highly virulent and low virulent strains of variola (smallpox) virus (VAR) recombinant plasmids determining synthesis of these proteins in E. coli cells have been constructed. The recombinant viral γ‐IFN receptor‐like proteins have been found to have high interferon‐neutralising activity with regards to human γ‐IFN but not murine γ‐IFN and human α‐IFN. The variola major and variola minor proteins under study do not differ in the efficiency of human γ‐IFN antiviral activity inhibition.