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Mechanisms of opsonized HIV entry in normal B lymphocytes
Author(s) -
Legendre Christophe,
Gras Gabriel,
Krzysiek Roman,
Galanaud Pierre,
Richard Yolande,
Dormont Dominique
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00040-3
Subject(s) - opsonin , human immunodeficiency virus (hiv) , virology , immunology , chemistry , antibody , biology
Using our in vitro model of normal B cell infection that functions with low doses of HIV but requires virus opsonization by seropositive patient serum, and complement, we analyzed what receptors allowed virus entry. Here, we show that HIV infection of B cells occurs through 2 major receptors: the CD4 antigen and the CR1/CR2 complex. These 2 pathways work independently since a complete inhibition of virus entry requires both CD4 and CD21/CD35 blockade on CD4 dim tonsillar B cells whereas only the latter is critical on CD4‐negative B cells.