Allelic forms of the knob associated histidine‐rich protein gene of  Plasmodium falciparum | Zendy

Kant Rajiv | Zendy; Sharma Yagya D. | Zendy

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Allelic forms of the knob associated histidine‐rich protein gene of Plasmodium falciparum

Author(s) -

Kant Rajiv,

Sharma Yagya D.

Publication year - 1996

Publication title -

febs letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.593

H-Index - 257

eISSN - 1873-3468

pISSN - 0014-5793

DOI - 10.1016/0014-5793(96)00024-5

Subject(s) - plasmodium falciparum , gene , biology , genetics , allele , histidine , malaria , virology , peptide sequence , sequence alignment , conserved sequence , microbiology and biotechnology , amino acid , immunology

The knob associated histidine‐rich protein (KAHRP) gene was cloned and sequenced from two Indian isolates of Plasmodium falciparum , Pf3‐92 and Pf29‐92. These isolates showed major sequence differences in the C‐terminal repeat domain of KAHRP. However, the biologically important domains such as spectrin‐actin binding region remained highly conserved. The PCR amplification of a variable C‐terminal repeat domain from the clinical isolates of P. falciparum , from Rajasthan epidemic, showed the presence of multiple alleles of KAHRP gene. The presence of multiple alleles indicates the existence of several P. falciparum strains in India. This should be taken into account for future malaria control strategies such as molecular therapy and vaccines.

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