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The SV40 T‐antigen induces premature apoptotic mammary gland involution during late pregnancy in transgenic mice
Author(s) -
Tzeng Y.J.,
Gottlob K.,
Santarelli R.,
Graessmann A.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(96)00021-x
Subject(s) - involution (esoterism) , lactation , mammary gland , transgene , genetically modified mouse , apoptosis , offspring , medicine , endocrinology , pregnancy , biology , breast milk , andrology , breast cancer , cancer , gene , genetics , consciousness , neuroscience , biochemistry
Transgenic animals of the line 8 contain the WAP‐SV‐T transgene. Females of this line synthesise the SV40 T‐antigen in mammary gland epithelial cells during pregnancy and the lactation period. All females are ‘milk‐less’ and the offspring have to be nursed by foster mothers. The reason for this phenomenon is a premature apoptosis during late pregnancy. Nonetheless a significant number of mammary epithelial cells escape apoptosis and all transgenic females develop breast cancer after the first lactation period.