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The nuclear‐encoded 18 kDa (IP) AQDQ subunit of bovine heart complex I is phosphorylated by the mitochondrial cAMP‐dependent protein kinase
Author(s) -
Papa Sergio,
Sardanelli Anna Maria,
Cocco Tiziana,
Speranza Francesco,
Scacco Salvatore C.,
Technikova-Dobrova Zuzana
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01532-9
Subject(s) - protein subunit , protein kinase a , phosphorylation , chemistry , kinase , microbiology and biotechnology , biochemistry , biology , gene
In bovine heart mitochondria a protein of M r 18 kDa, phosphorylated by mtPKA, is associated to the NADH‐ubiquinone oxidoreductase in the inner membrane and is present in purified preparation of this complex. The 18 kDa phosphoprotein has now been isolated and sequenced. It is identified as the 18 kDa (IP) AQDQ subunit of complex I, a protein of 133 amino acids with a phosphorylation consensus site RVS at position 129–131.