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Cerebrovascular amyloidosis in squirrel monkeys and rhesus monkeys: apolipoprotein E genotype
Author(s) -
Morelli Laura,
Wei LiHong,
Amorim Angela,
McDermid Jeanine,
Abee Christian R.,
Frangione Blas,
Walker Lary C.,
Levy Efrat
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01491-8
Subject(s) - apolipoprotein e , squirrel monkey , arginine , biology , subspecies , amyloidosis , phenotype , allele , genotype , medicine , genetics , disease , pathology , amino acid , neuroscience , zoology , gene
Some neuropathological changes characteristic of aging and Alzheimer's disease (AD) in humans are present also in senescent non‐human primates. The human apoE4 allele is associated with an increased risk of developing late‐onset familial and sporadic AD. We found that rhesus monkeys and three subspecies of squirrel monkeys are homozygous for apoE phenotype with arginine at positions 112 and 158 as in human apoE4. However, in both species threonine replaces arginine at position 61 of human apoE. It was previously shown that arginine 61 was critical in determining apoE4 lipoprotein distribution in humans.