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Protection against peroxynitrite‐dependent tyrosine nitration and α 1 ‐antiproteinase inactivation by oxidized and reduced lipoic acid
Author(s) -
Whiteman Matthew,
Tritschler Hans,
Halliwell Barry
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01489-6
Subject(s) - peroxynitrite , nitration , lipoic acid , tyrosine , chemistry , peroxynitrous acid , biochemistry , photochemistry , organic chemistry , antioxidant , superoxide , enzyme
Peroxynitrite, formed by combination of superoxide radical with nitric oxide, is a reactive tissue‐damaging species apparently involved in the pathology of several human diseases. Peroxynitrite nitrates tyrosine residues and inactivates α 1 ‐antiprotinase. We show that both lipoic acid and dihydrolipoic acid efficiently protect against damage by peroxynitrite. By contrast, other disulphides tested did not. The biological antioxidant effects of lipoate/dihydrolipoate may involve scavenging of reactive nitrogen species as well as reactive oxygen species.