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Differential effects of endogenous and exogenous nitric oxide on the release of endothelin‐1 from the intact perfused rat adrenal gland in situ
Author(s) -
Hinson J.P.,
Kapas S.,
Cameron L.A.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01467-5
Subject(s) - sodium nitroprusside , nitric oxide , endogeny , arginine , endocrinology , endothelin 1 , endothelin receptor , chemistry , medicine , vasodilation , secretion , biology , biochemistry , receptor , amino acid
Studies using an inhibitor of nitric oxide (NO) synthesis have suggested that endogenous NO may have a role in regulating endothelin release. We investigated the effect of endogenous and exogenous nitric oxide (NO) on the release of irET‐1. l ‐NAME stimulated, but l ‐arginine inhibited irET‐1 release. Perfusing sodium nitroprusside (SNP), however, did not inhibit irET‐1 secretion. CyclicGMP, the second messenger for NO action, was stimulated by SNP but not by l ‐arginine. These data demonstrate that endogenous NO inhibits of irET‐1, in a manner which is independent of cGMP, and suggest that this action may contribute to the vasodilatory effect of NO.