Premium
The 3D‐structure of a natural inhibitor of cell adhesion molecule expression
Author(s) -
Hommel Ulrich,
Weber Hans-Peter,
Oberer Lukas,
Ulrich Naegeli Hans,
Oberhauser Berndt,
Foster Carolyn A.
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01453-5
Subject(s) - molecule , adhesion , chemistry , hydrogen bond , cell adhesion molecule , cell adhesion , crystallography , crystal structure , peptide , biophysics , biochemistry , microbiology and biotechnology , biology , organic chemistry
The three‐dimensional structure of cyclopeptolide HUN‐7293, a naturally‐occurring inhibitor of cell adhesion molecule expression, has been determined from nuclear magnetic resonance data recorded in solution and from X‐ray diffraction analysis of single crystals. The backbone conformation of HUN‐7293 is characterized by two cis ‐peptide bonds in both the solution and crystalline state. Differences between the solution and crystal structure are visible for the orientation of some side chains and the strength of two transannular hydrogen bonds. Such structural information helps to provide insight into the molecular architecture of HUN‐7293 on the atomic level and opens the way for structure‐based modifications of this novel inhibitor of cell adhesion molecule expression.