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Stress signal, mediated by a Hogl‐like MAP kinase, controls sexual development in fission yeast
Author(s) -
Kato Tomohisa,
Okazaki Koei,
Murakami Hiroshi,
Stettler Sophie,
Fantes Peter A.,
Okayama Hiroto
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01442-x
Subject(s) - kinase , mitogen activated protein kinase , yeast , biology , microbiology and biotechnology , mutant , effector , signal transduction , ectopic expression , map kinase kinase kinase , protein kinase a , genetics , gene
We identified the phhl + gene that encodes a MAP kinase as the effector of Wis1 MAP kinase kinase in fission yeast, which is highly homologous with HOG1 of S. cerevisiae . Heterothalic phh1 dsiruptant is phenotypically indistinguishable from wis1 deletion mutant, both displaying the same extent of partial sterility and enhanced sensitivity to a variety of stress. In phh1 disruptant, nitrogen starvation‐induced expression of ste11 + , a key controller of sexual differentiation, is markedly diminished. Ectopic expression of ste11 + effectively restores fertility, but not stress resistance, to the phh1 disruptant. These data show that stress signal, mediated by a MAP kinase, is required for efficient start of sexual differentiation.