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Evolutionary relationship of hepatitis C, pesti‐, flavi‐, plantviruses, and newly discovered GB hepatitis agents
Author(s) -
Ohba Ken-ichi,
Mizokami Masashi,
Lau Johnson Y.N.,
Orito Etsuro,
Ikeo Kazuho,
Gojobori Takashi
Publication year - 1996
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01441-1
Subject(s) - virology , hepatitis c , hepatitis , medicine , biology
Two flavivirus‐like viruses, GB virus‐A (GBV‐A) and GB virus‐B (GBV‐B), were recently identified in the GB hepatitis agent, and are distinct from the hepatitis A to E viruses. The putative helicase domain of GBV‐A and GBV‐B was found to have amino acid sequence homology with hepatitis C virus (HCV), and distantly, is also related to pestiviruses, flaviviruses, and plant viruses. A phylogenetic tree construction showed that GBVs and HCV are closely related, and they are clustered with pestiviruses, flaviviruses and plant viruses in that order.