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Thrombopoietin induces activation of at least two distinct signaling pathways
Author(s) -
Yasunobu Nagata,
Kazuo Todokoro
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01386-5
Subject(s) - map kinase kinase kinase , ask1 , microbiology and biotechnology , signal transduction , thrombopoietin , mitogen activated protein kinase , mapk7 , chemistry , mapk14 , kinase , map2k7 , phosphorylation , mitogen activated protein kinase kinase , c raf , cyclin dependent kinase 9 , biology , cyclin dependent kinase 2 , cancer research , protein kinase a , protein kinase c , stem cell , haematopoiesis
Thrombopoietin (Tpo) is a cytokine regulating megakaryocyte maturation and platelet formation. We studied Tpo‐induced signal transduction, and found that Tpo induces phosphorylation of adapter molecules Shc and Vav, and of serine/threonine kinases Raf‐1 and mitogen‐activated protein (MAP) kinases. Further, Tpo induced activation of Ras, MAP kinase kinase, MAP kinase and Pim‐1. Taken together with other observations, we concluded that Tpo induces the activation of at least two distinct signaling pathways, a specific Tyk2‐JAK2/STAT1‐STAT3‐STAT5 signaling cascade and a common Shc/Vav/Ras/Raf‐1/MAP kinase kinase/MAP kinase signaling cascade.