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Human REG family genes are tandemly ordered in a 95‐kilobase region of chromosome 2p12
Author(s) -
Hidetoshi Miyashita,
Kan-ichi Nakagawara,
Mitsuko Mori,
Yoichi Narushima,
Naoya Noguchi,
Shigeki Moriizumi,
Shin Takasawa,
Hideto Yonekura,
Takuji Takeuchi,
Hiroshi Okamoto
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01381-4
Subject(s) - gene , genetics , biology , gene family , chromosome , complementary dna , microbiology and biotechnology , gene duplication , gene expression
Reg , first isolated from a rat regenerating islet cDNA library, is expressed in regenerating islet β ‐cells. Recently, it has been revealed that Reg and Reg ‐related genes constitute a multigene family, the Reg family. In human, the four REG family genes, i.e., REG Iα, REG Iβ, REG ‐related sequence ( RS ) and HIPIPAP , have so far been isolated. In this study, we analyzed YAC clones containing the four genes and performed two‐color FISH to determine the map order of the genes. The human REG family genes are tandemly ordered in the 95‐kbp DNA region of chromosome 2p12 as follows: 2cen‐ HIPIPAP‐RS‐REG Iα‐REG Iβ ‐ptel.