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Phylogenetic classification of the major superfamily of membrane transport facilitators, as deduced from yeast genome sequencing
Author(s) -
Nelissen Bart,
Mordant Philippe,
Jonniaux Jean-Luc,
Wachter Rupert De,
Goffeau André
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01380-6
Subject(s) - major facilitator superfamily , biochemistry , genome , phylogenetic tree , biology , genetics , yeast , saccharomyces cerevisiae , amino acid , membrane transport protein , membrane protein , computational biology , gene , transporter , membrane
From the approximately 5000 open reading frames presently identified by systematic sequencing of the yeast genome, 100 Saccharomyces cerevisiae transport proteins belonging to the major facilitator superfamily (MFS), were assigned to 17 families on the basis of extensive database searches and binary comparisons. These families include multidrug resistance proteins and transport proteins for sugars, amino acids, uracil/allantoin, allantoate, phosphate, purine/cytosine, proteins, peptides, potassium, sulfate, and urea. Four new families of unknown function have been identified. For the sugar and amino acid transport proteins, alignments were made and phylogenetic trees were constructed allowing the identification of several clusters of proteins presumably exhibiting similar transport functions.