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Interleukin‐10 induces interleukin‐11 responsiveness in human myeloma cell lines
Author(s) -
Zhaoqing Lu,
Zhifeng Gu,
X G Zhang,
John Wijdenes,
Petra Neddermann,
Jean François Rossi,
Bernard Klein
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01322-9
Subject(s) - autocrine signalling , receptor , multiple myeloma , interleukin , biology , interleukin 6 , gene expression , chemistry , immunology , gene , microbiology and biotechnology , cytokine , biochemistry
Interleukin (IL)‐6‐dependent human myeloma cell lines (HMCL) can be reproducibly obtained from patients with multiple myeloma and terminal disease. The growth of some of these HMCL can also be supported by IL‐11. We show that IL‐11‐responsive, but not ‐unresponsive, HMCL expressed the gene of human IL‐11 receptor (IL‐11R) and produced an autocrine IL‐10. All HMCL expressed the IL‐10 receptor. In addition, IL‐10 induced IL‐11R gene expression and conferred IL‐11 responsiveness on unresponsive HMCL. The ability of HMCL to produce IL‐10 was strictly correlated with the capacity of the original patient's myeloma cells to produce IL‐10 or not, and with the presence or absence of IL‐10 in the patient's plasma.