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Fibroblasts transformed by combinations of ras , myc and mutant p53 exhibit increased phosphorylation of histone H1 that is independent of metastatic potential
Author(s) -
Taylor William R.,
Chadee Deborah N.,
Allis C.David,
Wright Jim A.,
Davie James R.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01314-8
Subject(s) - phosphorylation , mutant , histone , chromatin , phenotype , biology , microbiology and biotechnology , cancer research , chemistry , gene , genetics
H1 histones play an important role in regulating higher order structure of chromatin and are potential regulators of gene expression. H1s are phosphorylated, a modification which alters their interaction with DNA. We measured the abundance of three phosphorylated H1 subtypes in mouse fibroblasts transformed by combinations of ras , myc and mutant p53 which differ in metastatic potential. We found that there is an increase in phosphorylation of H1 subtypes in fibroblasts transformed with ras , myc and mutant p53. This increase was found to correlate with cellular transformation but not with induction of the metastatic phenotype.