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Activin A‐induced apoptosis is suppressed by BCL‐2
Author(s) -
Koseki Takeyoshi,
Yamato Kenji,
Krajewski Stanislaw,
Reed John C.,
Tsujimoto Yoshihide,
Nishihara Tatsuji
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01290-7
Subject(s) - activin type 2 receptors , apoptosis , acvr2b , microbiology and biotechnology , cell culture , transforming growth factor , tgf beta signaling pathway , programmed cell death , chemistry , cell , biology , cancer research , biochemistry , genetics
Activin A, a member of TGFβ superfamily has various activities including induction of apoptosis in mammalian cells. However, it remains unknown how activin A induces cell death. To clarify this, we investigated the expression of BCL‐2 and BAX, and the effect of BCL‐2 overexpression on activin A‐induced apoptosis in B cell hybridoma cell lines. The activin A‐sensitive cell lines expressed BAX but not BCL‐2 and that activin A did not increase BAX levels. Overexpression of human BCL‐2 suppressed activin A‐induced apoptosis in these cells. Thus, activin A has been shown to induce apoptosis by a BCL‐2‐inhibitable mechanism without activating BAX.