Premium
The osmo‐inducible gpdl + gene is a target of the signaling pathway involving Wis1 MAP‐kinase kinase in fission yeast
Author(s) -
Aiba Hirofumi,
Yamada Hisami,
Ohmiya Ryusuke,
Mizuno Takeshi
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01277-4
Subject(s) - glycerol kinase , schizosaccharomyces pombe , kinase , biology , osmotic concentration , biochemistry , yeast , signal transduction , gene , osmotic shock , microbiology and biotechnology , saccharomyces cerevisiae
The gpd1 + gene of Schizosaccharomyces pombe encodes an isozyme of NADH‐dependent glycerol‐3‐phosphate dehydrogenases that is involved in glycerol synthesis, whose expression is induced upon an upshift of the medium osmolarity. We provide evidence that this osmotic induction of gpd1 + in S. pombe is under the control of a MAP‐signaling pathway involving the wis1 + gene‐product, which is a homologue of MAP‐kinase kinases. The results suggested that the gpd1 + gene is a downstream target of the osmosensing signaling that is transmitted through Wis1, thereby defects of either of these genes result in the similar phenotype, namely, osmosensitive for growth, because of the failure in accumulation of the intracellular osmoprotectant, glycerol.