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Circumvention of multidrug resistance in neoplastic cells through scavenger receptor mediated drug delivery
Author(s) -
Mukhopadhyay Amitabha,
Mukhopadhyay Bratati,
Basu Sandip K.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01250-6
Subject(s) - multiple drug resistance , scavenger receptor , intracellular , pharmacology , cell culture , efflux , drug resistance , receptor , chemistry , scavenger , cancer research , biology , biochemistry , microbiology and biotechnology , radical , genetics , lipoprotein , cholesterol
A conjugate of the antineoplastic drug daunomycin (DNM) with maleylated bovine serum albumin (MBSA‐DNM) was taken up with high efficiency by a multidrug resistant variant, JD100, of the murine‐macrophage tumour cell line, J774A.1, through the scavenger receptors resulting in cessation of DNA synthesis. In contrast, free DNM at similar concentrations did not affect the incorporation of [ 3 H]thymidine by these cells. These results suggest that receptor‐mediated intracellular delivery of antineoplastic drugs could be a viable and new approach for overcoming the problem of multidrug resistance in chemotherapy of neoplastic diseases.