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Secretion of laminin α2 chain in cerebrospinal fluid
Author(s) -
Yamada Hiroki,
Hori Hisae,
Tanaka Takeshi,
Fujita Sachiko,
Fukuta-Ohi Hiroko,
Hojo Shuntaro,
Tamura Akira,
Shimizu Teruo,
Matsumura Kiichiro
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01240-3
Subject(s) - laminin , congenital muscular dystrophy , cerebrospinal fluid , myelinogenesis , choroid plexus , glycoprotein , secretion , chemistry , biology , pathology , endocrinology , muscular dystrophy , medicine , microbiology and biotechnology , extracellular matrix , central nervous system , myelin , oligodendrocyte
The absence of laminin α2 chain causes muscle cell degeneration and peripheral dysmyelination in congenital muscular dystrophy patients and dy mice, suggesting its role in the maintenance of sarcolemmal architecture and peripheral myelinogenesis. Here we demonstrate the secretion of laminin α2 chain in cerebrospinal fluid (CSF). Laminin α2 chain was detected as a minor component of the total CSF proteins or glycoproteins. Laminin α2 chain was localized in the cytoplasm of epithelial cells of choroid plexus, suggesting active secretion. Our results suggest that immunochemical analysis of CSF laminin α2 chain could be useful as an aid for the diagnosis of congenital muscular dystrophy.