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Amino acid residue: is it structural or functional?
Author(s) -
Golovanov Alexander P.,
Efremov Roman G.,
Jaravine Victor A.,
Vergoten Gérard,
Arseniev Alexander S.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01212-w
Subject(s) - amino acid residue , residue (chemistry) , amino acid , intramolecular force , rational design , structural similarity , chemistry , biochemistry , protein engineering , protein structure , peptide sequence , stereochemistry , biophysics , computational biology , biology , enzyme , genetics , gene
A new approach is suggested for delineating the structural and functional amino acid residues in proteins with known three‐dimensional structure, basing on the involvement of residues in intramolecular hydrophobic and hydrophilic interactions and additional information about the conservativity of the residues. The approach is applied to the families of homologous neurotoxins and cardiotoxins. The results obtained concerning the role of amino acid residues in both families of toxins accord well with the similarity of their fold, but different mechanisms of action. Current approach can be used for detailed characterization of protein spatial structures, as well as for rational protein engineering.