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Sequence‐specific DNA binding activity of rat cdc 37‐related gene product
Author(s) -
Ozaki Toshinori,
Sakiyama Shigeru
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01210-6
Subject(s) - gene , sequence (biology) , dna , gene product , product (mathematics) , genetics , biology , chemistry , microbiology and biotechnology , gene expression , mathematics , geometry
The rat cdc37 ‐related gene product (RCdc37), which is possibly involved in the regulation of cell cycle progression, contains a putative basic/leucine zipper (bZIP) domain in its N‐terminal portion. In this study, we have identified a rat genomic sequence which can interact with RCdc37 using an in vitro binding assay. The specificity of this interaction was confirmed by gel retardation experiments. These results raise a possibility that RCdc37 might play an important role in the control of cell cycle progression via a sequence‐specific DNA binding mechanism.