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An immunodominant antigen of Brugia malayi is an asparaginyl‐tRNA synthetase
Author(s) -
Kron Michael,
Marquard Kristine,
Härtlein Michael,
Price Steven,
Leberman Reuben
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01092-s
Subject(s) - brugia malayi , lymphatic filariasis , onchocerca volvulus , biology , wuchereria bancrofti , antigen , virology , aminoacyl trna synthetase , filariasis , transfer rna , gene , immunology , helminths , genetics , onchocerciasis , rna
Lymphatic filariasis is caused by infection with the filarial nematodes Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca volvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode antigen suggested that it was a class II aminoacyl‐tRNA synthetase. The overproduction, purification and verification that the major B. malayi antigen is an asparaginyl‐tRNA synthetase is described.