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Distribution of mRNA encoding the inwardly rectifying K + channel, BIR1 in rat tissues
Author(s) -
Dixon A.K.,
Gubitz A.K.,
Ashford M.L.J.,
Richardson P.J.,
Freeman T.C.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01091-r
Subject(s) - messenger rna , chemistry , physics , distribution (mathematics) , biophysics , microbiology and biotechnology , biology , gene , biochemistry , mathematical analysis , mathematics
The distribution of mRNA encoding the inwardly rectifying K + channel, BIR1 [1] was investigated in rat tissues, and a comparison made with the expression of related genes rcK ATP and GIRK1 using the reverse transcription‐polymerase chain reaction (RT‐PCR). This showed BIR1 to be expressed in all areas of the brain examined, in the eye but not in any other peripheral tissue. This pattern was distinct from rcK ATP and GIRK1. Additional in situ hybridisation studies of the central expression of BIR1 demonstrated high levels of BIR1 mRNA in the hippocampus dentate gyrus, taenia tecta and cerebellum and at lower levels in the cortex, habenular nucleus, olfactory bulb, primary olfactory cortex, thalamus, pontine nucleus and amygdaloid nucleus.