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A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon
Author(s) -
Lundwall Åke,
Lazure Claude
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01076-q
Subject(s) - exon , gene , genetics , biology , signal peptide , gene family , exon trapping , transcription (linguistics) , exon shuffling , tandem exon duplication , peptide sequence , alternative splicing , genome , linguistics , philosophy
Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3′ non‐translated nucleotides. The first and and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.