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The expression of the imprinted H19 and IGF‐2 genes in human bladder carcinoma
Author(s) -
Elkin Michael,
Shevelev Alexander,
Schulze Ekkehard,
Tykocinsky Mark,
Cooper Mark,
Ariel Ilana,
Pode Dov,
Kopf Eliezer,
de Groot Nathan,
Hochberg A.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01074-o
Subject(s) - carcinoma , genomic imprinting , rna , gene expression , cancer research , imprinting (psychology) , gene , transitional cell carcinoma , bladder cancer , human bladder , biology , messenger rna , pathology , cancer , medicine , genetics , dna methylation
The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF‐2 was observed in samples of human bladder carcinoma.