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The role of the skeletal muscle myosin light chains N‐terminal fragments
Author(s) -
Stȩpkowski Dariusz
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01049-k
Subject(s) - myosin light chain kinase , myosin head , myosin , immunoglobulin light chain , actin , skeletal muscle , biophysics , chemistry , phosphorylation , meromyosin , microbiology and biotechnology , biochemistry , biology , anatomy , genetics , antibody
The myosin regulatory and essential light chains in skeletal muscle do not play a role as significant as in scallop or smooth muscle, however, there are some data suggesting that the skeletal myosin light chains and their N‐terminal parts may have a modulatory function in the interaction of actin with myosin heads. In this paper four conformational states of the myosin head with respect to the regulatory light chain bound cation (magnesium or calcium) and phosphorylation are proposed. Communication between regulatory and essential light chains and putative binding of the N‐terminus of A1 essential light chain to actin is discussed.