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Lasp‐1 (MLN 50) defines a new LIM protein subfamily characterized by the association of LIM and SH3 domains
Author(s) -
Tomasetto Catherine,
Moog-Lutz Christel,
Régnier Catherine H.,
Schreiber Valérie,
Basset Paul,
Rio Marie-Christine
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01040-l
Subject(s) - sh3 domain , lim domain , subfamily , complementary dna , homology (biology) , biology , microbiology and biotechnology , proto oncogene tyrosine protein kinase src , ww domain , genetics , gene , kinase , zinc finger , transcription factor
MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c‐erb B‐2. MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp‐1 ( IM and H3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino‐ and the C‐terminal parts of the protein, respectively. Thus, Lasp‐1 defines a new LIM protein subfamily.