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Purification from human plasma of a tetrapeptide that potentiates insulin‐like growth factor‐I activity in chick embryo cartilage
Author(s) -
Straczek J.,
Maachi F.,
Le Nguyen D.,
Becchi M.,
Heulin M.H.,
Nabet P.,
Belleville F.
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01037-f
Subject(s) - edman degradation , cartilage , embryo , chemistry , peptide , tetrapeptide , glycosaminoglycan , growth factor , biochemistry , biology , peptide sequence , microbiology and biotechnology , gene , anatomy , receptor
Human plasma has been shown to contain a low molecular weight factor that potentiates human IGF‐I stimulation of glycosaminoglycan synthesis in chick embryo cartilage. The peptide was purified and characterized by Edman degradation and electrospray mass spectrometry. The primary structure determined was: Trp‐Gly‐His‐Glu. A homologous synthetic peptide similarly promoted matrix biosynthesis in cartilage exposed to IGF‐1.