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Alternative splicing of AMPA receptor subunits: regulation in clonal cell lines
Author(s) -
Christnacher Alexandra,
Sommer Bernd
Publication year - 1995
Publication title -
febs letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.593
H-Index - 257
eISSN - 1873-3468
pISSN - 0014-5793
DOI - 10.1016/0014-5793(95)01016-8
Subject(s) - ampa receptor , splice , alternative splicing , rna splicing , protein subunit , messenger rna , microbiology and biotechnology , receptor , biology , gene , rna , glutamate receptor , genetics
Alternative splicing of AMPA receptors was investigated in rat PC12 and human SH‐SY5Y cells. PC12 cells predominantly expressed GluR‐B flip mRNA before and after differentiation. In SH‐SY5Y cells, each AMPA‐receptor subunit showed a distinct splice variant expression profile throughout differentiation. GluR‐B mRNA was comparable in expression levels for flip and flop splice variants. In the other AMPA‐receptor subunit transcripts the flip form was the more prominent splice variant. After three days post induction a transient elevation of GluR‐B and ‐D flop mRNA expression could be observed.